Top line:
Genetic predisposition to gout, unfavorable lifestyle habits, and poor metabolic health are associated with increased risk of cardiovascular disease (CVD). However, by adhering to a healthy lifestyle, this risk can be reduced by up to 62%, even in people with a high genetic risk.
Methodology:
Researchers investigated the association between genetic predisposition to gout in combination with lifestyle and CVD risk in two diverse prospective cohorts with different ancestry backgrounds. They analyzed data from 224,689 participants of European descent from the UK Biobank (mean age 57.0 years). Genetic predisposition to gout was assessed using a polygenic risk score (PRS) derived from: It was a metagenome-wide association study, and participants were categorized into low, intermediate, and high genetic risk groups based on their gout PRS. A favorable lifestyle was defined as having three or more healthy lifestyle factors and zero to one metabolic syndrome factor. Ideal metabolic health. The risk of developing cardiovascular disease was assessed based on genetic risk, lifestyle, and metabolic syndrome.
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The UK Biobank (adjusted hazard ratio (aHR), 1.10; P < .001) and KoGES (aHR, 1.31; P = UK Biobank cohorts had higher genetic risk for gout and unfavorable lifestyle choices. Similar results were observed in the UK Biobank cohort as well. In KoGES, those with high genetic risk for gout and poor metabolic health had a 2.16 times higher risk of CVD compared to those with low genetic risk (aHR, 2.16; P<.001 for both); KoGES Results did not differ between cohorts: Improving metabolic health and adhering to a healthy lifestyle reduced the risk of CVD by 62% in those with high genetic risk and 46% in those with low genetic risk. % decreased (both P < .001).
actual:
“PRS for gout can be used to prevent not only gout but also CVD. It can identify people who are genetically at high risk for gout and strongly recommend lifestyle changes such as weight loss, smoking cessation, regular Exercise, healthy eating are effective strategies to prevent gout and CVD,” the authors write.
sauce:
The study was led by Ki Won Moon, MD, of the Department of Internal Medicine, Gangwon National University School of Medicine, Chuncheon, South Korea, and Sang‑Hyuk Jung, PhD, of the University of Pennsylvania in Philadelphia, and was published online. RMD opens on October 8, 2024.
Limitations:
Lifestyle and definitions of metabolic syndrome differed in each cohort, which may have influenced the study results. Data on lifestyle behaviors and metabolic health status were collected at enrollment, but these variables may have changed during the follow-up period, potentially introducing bias into the results. This study was unable to establish a causal relationship between genetic predisposition to gout and risk of developing cardiovascular disease.
Disclosure:
This research was supported by the National Institute of General Medical Sciences and the National Research Foundation of Korea. The authors declare that they have no competing interests.
This article was created using several editing tools, including AI as part of the process. A human editor reviewed this content before publication.
